Erosil

Treatment of erectile dysfunction, defined as the inability to achieve and maintain a penile erection necessary for successful sexual intercourse. Sexual arousal is required for Erosil to work effectively.

Contraindication.

• Hypersensitivity to sildenafil or to other components of the drug.
• Concomitant use with nitric oxide donors (such as amyl nitrite) or nitrates in any form, as sildenafil is known to affect the metabolic pathways of nitric oxide / cyclic guanosine monophosphate (cGMP) and potentiate the hypotensive effect of nitrates.
• Diseases for which sexual activity is not recommended (eg, severe cardiovascular disorders such as unstable angina and severe heart failure).
• Loss of vision in one eye due to non-arterial anterior ischemic optic neuropathy, regardless of whether this pathology is associated with previous use of PDE5 inhibitors.
• Severe hepatic impairment, hypotension (blood pressure below 90/50 mm Hg), recent stroke or myocardial infarction, and known inherited retinal degenerative diseases such as retinitis pigmentosa (a small number of such patients have genetic disorders of the retinal phosphodiesterase), as the safety of sildenafil has not been studied in patients with such diseases.

The tablets are intended for oral administration. Sexual arousal is required to realize the effect of sildenafil.
The recommended dose of Erosil is 50 mg and is used as needed approximately 1 hour before sexual intercourse. Depending on the effectiveness and tolerability of the drug, the dose can be increased to 100 mg or reduced to 25 mg. (tablets in the appropriate dosage are used). The maximum recommended dose is 100 mg. The maximum recommended frequency of application is once a day. When using the drug Erosil during a meal, its effect may occur later than when used on an empty stomach.

Elderly patients.
There is no need for dose adjustment for elderly patients. Patients with renal insufficiency. For patients with mild to moderate renal impairment (creatinine clearance 30 to 80 ml / min), the recommended dose is similar to the dose above. Because sildenafil clearance is reduced in patients with severe renal impairment (creatinine clearance <30 ml / min), the recommended dose is 25 mg. (tablets in the appropriate dosage are used). Depending on the effectiveness and tolerability of the drug, the dose can be increased to 50 mg and 100 mg.

Patients with hepatic insufficiency.
Because sildenafil clearance is reduced in patients with hepatic impairment (eg, liver cirrhosis), the recommended dose is 25 mg. (tablets in the appropriate dosage are used). Depending on efficiency and tolerability
drug dose can be increased to 50 mg or 100 mg.

Patients taking other drugs.
The recommended starting dose for patients taking CYP3A4 inhibitors, with the exception of ritonavir, is 25 mg. (tablets in the appropriate dosage are used). To reduce the risk of orthostatic hypotension, patients taking α-adrenoceptor blockers should be stabilized prior to initiating sildenafil. Also, the recommended starting dose of sildenafil is 25 mg (tablets in the appropriate dosage are used).

Children.
The drug is not used in children.